MIDEAST DIPLOMACY: White House press secretary Karoline Leavitt announced President Trump has spoken with numerous Middle East leaders following the joint US-Israel attack on Iran.

DUBAI, United Arab Emirates (AP) — The U.S. and Israel launched a major attack on Iran on Saturday, with President Donald Trump calling on the Iranian public to “seize control of your destiny” and rise up against the Islamic leadership that has ruled the nation since 1979.

Some of the first strikes appeared to hit areas around the offices of Supreme Leader Ayatollah Ali Khamenei, and Iranian media reported strikes nationwide. Smoke could be seen rising from the capital. It wasn’t immediately clear whether the 86-year-old leader was in his offices at the time of the strike.

When we are finished, take over your government. It will be yours to take. This will be probably your only chance for generations,” Trump said in a video announcing “major combat operations” were underway. “For many years, you have asked for America’s help, but you never got it.”

Israeli Prime Minister Benjamin Netanyahu echoed that sweeping goal. “Our joint operation will create the conditions for the brave Iranian people to take their fate into their own hands,” Netanyahu said.

The strikes opened a stunning new chapter in U.S. intervention in Iran and marked the second time in eight months that the Trump administration has used military force against the Islamic Republic. They also came just weeks after Trump ordered a military operation to capture Venezuela’s president, Nicolás Maduro, and bring him and his wife to New York to face federal drug conspiracy charges.

They came after tensions soared in recent weeks as American warships moved into the region, and Trump said he wanted a deal to constrain Iran’s nuclear program at a moment when the country is struggling at home with growing dissent following nationwide protests.